Penicillin-resistant Streptococcus pneumoniae: selection by both β-lactam and non-β-lactam antibiotics

Kinetics of β -Lactam Interactions with Penicillin-Susceptible and -Resistant Penicillin-Binding Protein 2x Proteins from Streptococcus pneumoniae: Involvement of Acylation and Deacylation in β -Lactam Resistance

β-Lactam Antibiotics Renaissance.

Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However, emergence and dissemination of β-lactam resistance has reached the point where many marketed β-lactams no longer are clinically effective. The increasing prevalence of multidrug-resistant bacteria and the progressive withdrawal of pharmaceutical companies from antibiotic research have evoked a strong rea...

In-vitro activity of 21 beta-lactam antibiotics against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae.

MICs of 21 beta-lactams were determined by agar dilution against 283 penicillin-susceptible (pen-S), 122 intermediate (pen-I) and 23 fully penicillin-resistant (pen-R) pneumococci. MICs of all beta-lactams increased with increasing MICs of penicillin. Clometocillin was the most active penicillin against pen-I or pen-R pneumococci. All oral cephalosporins except cefuroxime and cefpodoxime were l...

Degradation of β-lactam antibiotics

Recent developments in the chemistry and biology of βlactam antibiotics which culminated with the introduction of several clinically useful classical and nonclassical β-lactams have been most thrilling and highly rewarding. While this review touches upon the historical development of β-lactams and their reactivity in a nutshell, it provides an overview of various aspects of chemical and enzymat...

Penicillin-Binding Protein Transpeptidase Signatures for Tracking and Predicting β-Lactam Resistance Levels in Streptococcus pneumoniae

UNLABELLED β-Lactam antibiotics are the drugs of choice to treat pneumococcal infections. The spread of β-lactam-resistant pneumococci is a major concern in choosing an effective therapy for patients. Systematically tracking β-lactam resistance could benefit disease surveillance. Here we developed a classification system in which a pneumococcal isolate is assigned to a "PBP type" based on seque...